Tablet coating is a crucial pharmaceutical manufacturing process characterized by high temperatures ranging from 70 to 90°C and a very low dew point between 0 to -10°C.
In the coating pan for tablets, heavy sugar solution is added to the tumbling mass during the tablet coating process. As the water evaporates, sugar crystals cover each piece. Blowing the proper quantity of air at the correct dry and wet bulb temperatures forms smooth, opaque coating. If cooling and drying are not at the desired rate, the coating gets rough, translucent, and unsatisfactorily in appearance; if too fast, the coating chips through to the interior.
Impact of Uncontrolled Temperature and Dew Point
Inadequate dry air during the coating process can give rise to a pitting problem, ultimately affecting the aesthetic quality of the tablets. Pitting manifests as small depressions or imperfections on the tablet surface, compromising its smooth and glossy appearance. Precise control of temperature and dew point is extremely important in preventing this issue.
Recommendation
Ensuring the recommended temperature and dew point parameters are essential for the overall quality of the final pharmaceutical product. This will guarantee not only visual appeal but also the effectiveness and stability of the medication.
Application |
Temperature |
Dew Point (°C) |
°C |
°F |
Tablet Coating |
70 – 90 |
158 – 194 |
0 – (-) 10 |
Bry-Air Solution
Bry-Air Desiccant dehumidifiers can maintain RH as low as 1% or even lower at constant level, regardless of ambient conditions. These dehumidifiers are CNC fabricated with powder coated finish incorporating high performance Metal Silicate Fluted media, which is bacteria static, non-toxic and thus, ideal to meet GMP requirements of the pharmaceutical industry.